Availability: In StockBiological Description:Tofacitinib(CP-690550) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.IC50 value: 1 nM [1]Target: JAK3in vitro: CP-690550 is a specific, orally inhibitor of JAK3, it is 20- to 100-fold less potent for JAK2 and JAK1 with IC50 of 20 nM and 112 nM, respectively. CP-690550 doesn"t have potent activity against 30 other kinases (all median IC50 > 3000 nM). CP-690,550 inhibits IL-2–induced proliferation with 30-fold greater potency than its effects on GM-CSF–induced proliferation [1]. CP-690550 effectively inhibits a murine mixed lymphocyte reaction (MLR) (IC50 = 91 nM) [2]. CP-690550 potently inhibits IL-4 induced upregulation of CD23 (IC50=57 nM) and class II major histocompatibility complex (MHCII) expression (IC50=71 nM) on murine B cells [3]. in vivo: In a murine model of heterotopic heart transplantation (DBA2 donor heart into C57/BL6 host), CP-690550 results in a dose-dependent increase in survival of transplanted hearts.The EC50 (drug concentrati...Purity: >98%Molecular formula: C₁₆H₂₀N₆OMolecular Weight: 312.37Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/ Affix Scientific毒素和天然物质乙酰肾上腺素（14-）CAS号： 71609-79-5化学名称：71609-79-5> 99％20毫克100毫克$ 500$ 1500乌头碱CAS号： 302-27-2化学名称：302-27-2> 98％100毫克500毫克$ 500$ 1600乌头酸CAS号： 38839-95-1化学名称：38839-95-1> 98％20毫克100毫克$ 500$ 1400阿科林CAS号： 110225-59-7化学名称：110225-59-7> 98％20毫克100毫克$ 500$ 1500茉莉花CAS号： 509-17-1化学名称：509-17-1> 98％20毫克100毫克$ 500$ 1200阿苯达唑CAS号： 54965-21-8化学名称：54965-21-8> 98％200毫克1000毫克$ 500$ 1300别氯CAS号： 141489-39-6化学名称：141489-39-6> 80％100毫克500毫克$ 500$ 1700