Availability: In StockBiological Description:(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2).IC50 Value: 77 nM(for BRD4(1)); 33 nM( for BRD4(2))Target: BRD4in vitro: (+)-JQ1 enantiomer binds directly into the Kac binding site of BET bromodomains. (+)-JQ1 (500 nM) binds BRD4 competitively with chromatin resulting in differentiation and growth arrest of NMC cells. (+)-JQ1 (500 nM) attenuates rapid proliferation of NMC 797 and Per403 cell lines as demonstrated by reduced Ki67 staining. (+)-JQ1 (500 nM) potently decreases expression of both BRD4 target genes in NMC 797 cells. (+)-JQ1 inhibits cellular viability with IC50 of 4 nM in NMC 11060 cells. (+)-JQ1 results in robust inhibition of MYC expression in MM cell lines. (+)-JQ1 inhibits proliferating of KMS-34 and LR5 with IC50 of 68 nM and 98 nM, respectively. (+)-JQ1 (500 nM)-treated MM.1S cells results in a pronounced decrease in the proportion of cells in S-phase, with a concomitant increase in cells arrested in G0/G1. (+)-JQ1 (500 nM) results in pronounced cellu...Purity: >98%Molecular formula: C₂₃H₂₅ClN₄O₂SMolecular Weight: 456.99Storage Instructions: Two years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSOReferences: for more information, please visit images/AffixScientific/ Affix Scientific毒素和天然物质乙酰肾上腺素（14-）CAS号： 71609-79-5化学名称：71609-79-5> 99％20毫克100毫克$ 500$ 1500乌头碱CAS号： 302-27-2化学名称：302-27-2> 98％100毫克500毫克$ 500$ 1600乌头酸CAS号： 38839-95-1化学名称：38839-95-1> 98％20毫克100毫克$ 500$ 1400阿科林CAS号： 110225-59-7化学名称：110225-59-7> 98％20毫克100毫克$ 500$ 1500茉莉花CAS号： 509-17-1化学名称：509-17-1> 98％20毫克100毫克$ 500$ 1200阿苯达唑CAS号： 54965-21-8化学名称：54965-21-8> 98％200毫克1000毫克$ 500$ 1300别氯CAS号： 141489-39-6化学名称：141489-39-6> 80％100毫克500毫克$ 500$ 1700