安倍经济学/咪唑喹啉树脂基莫特(R-848)/1mg/15-1016

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¥3500.00
货号:15-1016
浏览量:127
品牌:Abeomics
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商品描述

Amount :500ug, 1mg/ml
Purification :Purity≥98%
Content :liquid (1 mg/ml)
Storage condition :Store the product at 4°C for short term and at -20°C for long-term storage. Product is stable for 2 years at -20°C.
Alternative Name :Resiquimod; S 28463; R848
Formula: C17H22N4O2
MW: 314.4
Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines, potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-κB,NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I.Upregulator of the opioid growth factor receptor.Used in the treatment of skin lesions such as herpes simplex virus.

Solubility: Soluble in DMSO, dichloromethane or methanol. Slightly soluble in acetonitrile or ethyl acetate.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Abeomics的TLR6单克隆抗体(克隆:ABM1B50)TLR6(Toll样受体6)是TLR(Toll样受体)家族的成员,在病原体识别和先天免疫激活中起着基本作用。TLR6与TLR1和TLR2形成异二聚体,这是一连串事件的第一步,这些事件导致明显的先天免疫反应,对病原体的适应性免疫的发展以及对与这些病原体感染相关的免疫后遗症的保护。TLR2与TLR6协同通过激活NF-κB激活炎症分子的转录,触发炎症反应。TLR6已成为ZNPs(氧化锌纳米粒子)诱导的炎症反应的最有效激活剂。沉默后,TLR6显着抑制促炎细胞因子水平,