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abbomax/Cdk9/100ug/602-390

价格
面议
货号:602-390
浏览量:110
品牌:abbomax
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Cdk9
cyclin-dependent kinase 9
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Product Preparation
A synthetic peptide corresponding to the C-terminus of mouse PLAC1 protein (from 145aa-175aa).This sequence is identical to human, rat and mouse.
Background
The PLAC1, a placenta-specific gene, which encodes a putative cell surface protein, is highly expressed in placenta, testis, cancer cell lines and lung tumors.PLAC1 is exclusively expressed by cells of trophoblastic lineage in the mouse, and maps to a region of the X-chromosome known to be important in placenta growth.PLAC1 is also expressed in human hepatocellular cancer tissues as well as in several other types of cancer tissues and/or tumor cell lines. PLAC1 represents a new class of tumor associated antigen with restricted expression in placenta and cancer tissues, that may serve as a target for cancer vaccination.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
SPECIFICITY
This antibody recognizes ~22 kDa of PLAC1 protein. It cross-reacts to human, rat and mouse. The other species are not tested.
FORMULATION
This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
STORAGE
The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity.Avoid repeated freezing-thawing cycles.
Gene ID
1025
Applications/Suggested Working Dilutions
Western Blot
0.1-1 µg/ml
ELISA
0.01-0.1 µg/ml
Immunoprecipitation
2-5µg/ml
IHC
2-10µg/ml
Flow cytometry
5-10µg/ml
abbomax的14-3-3蛋白是一类小而广泛表达的高度保守的胞质蛋白。14-3-3蛋白与包括Raf,PKC,Bad,Cbl和c-Bcr在内的信号转导,细胞周期调控和细胞凋亡的各种分子结合并影响其活动。14-3-3与靶蛋白之间的相互作用受14-3-3与靶蛋白的磷酸化状态强烈影响。14.3.3β在脑组织中高度表达。这对于细胞转化和有丝分裂信号传导至关重要。