CatalogNo.: K-5000A Description: EchelonBioscience’sHumanAnti-PEthAutologousIgGELISAisadirectassayinwhichthesignalisproportionaltotheamountofautologousanti-PEthIgGcontainedinthesample.Theserum(orplasma)sampleisaddedtoaPEth-coatedplateforbinding.Aperoxidase-linkedsecondarydetectorandcolorimetricsubstrateareusedtodetecttheamountofanti-PEthantibodyboundtotheplate.Thecolorimetricsignalisreadatabsorbance450nmandisdirectlyproportionaltotheamountofautologousanti-PEthIgGinthesample.
Ethanol(EtOH)hasmultipleeffectsonhumansandotheranimals.Alcoholaddictionandorgandamageareactiveareasofresearchwithaneedforresearchreagentsandtools.1Phosphatidylethanol(PEth)isadirectmetaboliteofEtOHandhasbeendescribedasalong-livedbioMarkerforalcoholingestion.2,3ItispossIBLethatPEthisinvolvedintheneurological4,protective5,andharmful6effectsofalcohol,butthemechanismsarestillbeingexplored. Autologousanti-PEthantibodiesarefoundinlowerabundanceinserumfromheavierdrinkers.Thisinverserelationshipbetweenanti-PEthIgGlevelsandalcoholingestionwasfirstreported,byNissinenet.al.7EvaluationofserumsamplesofvaryingconsumptionhABItshasdemonstratedahighdegreeofcorrelationwithingestedalcohol.Measuringtheseautologousanti-PEthIgGlevelsmayserveasaneffectivebiomarkerinmonitoringalcoholuse. Storage 4°C References 1.Freeman,W.M.;Vrana,K.E.FutureProspectsforbiomarkersofalcoholconsumptionandalcohol-induceddisorders.AlcoholClinExpRes2010,34,946-54. 2.Viel,G.;etal.Phosphatidylethanolinbloodasamarkerofchronicalcoholuse:asystematicreviewandmeta-analysis.IntJMolSci2012,13,14788-812. 3.Wurst,F.M.;etal.Phosphatidylethanol:normalizationduringdetoxification,genderaspectsandcorrelationwithotherbiomarkersandself-reports.AddictBiol2010,15,88-95. 4.Esteban-Pretel,G.;etal.PolyphosphoinositidemetabolismandGolgicomplexmorphologyinhippocampalneuronsinprimarycultureisalteredbychronicethanolexposure.AlcoholAlcohol2012,48,15-27. 5.Foster,D.A.;etal.Reducedmortalityandmoderatealcoholconsumption:thephospholipaseD-mTORconnection.CellCycle2010,9,1291-4. 6.Pannequin,J.;atal.PhosphatidylethanolaccumulationpromotesintestinalhyperplasiabyinducingZONAB-mediatedcelldensityincreaseinresponsetochronicethanolexposure.MolCancerRes2007,5,1147-57. 7.Nissinen,A.E.;etal.Lowplasmaantibodiesspecificforphosphatidylethanolinalcoholabusersandpatientswithalcoholicpancreatitis.AddictBiol,2011.17(6):p.1057-67. RelatedProducts PhosphatidylethanolELISA(K-5000) Anti-PhosphatidylethanolAntibody(Z-PETH) Phosphatidylethanolcoatedbeads(P-BPEth) SyntheticPhosphatidylethanols

Echelon常用产品报价单产品名货号公司分类商城分类美金价Echelon/Anti-Rat F1-ATP Synthase Alpha Subunit Rabbit Polyclonal Antibody/100 UL/Z-RATPAZ-RATPA功能性抗体400.00Echelon/Biotinylated Anti-PtdIns(3,4)P2 IgG/50 UG/Z-B034Z-B034其它重组蛋白586.00Echelon/Goat anti-human Autotaxin antibody/10 UG/Z-P400Z-P400抗人83.00Echelon/PI4-Kinase beta (PI4Kb), active/5 UG/P32-102GP32-102G激酶226.00Echelon/1-Methylhistamine dihydrochloride/25 MG/B-0032B-0032其他试剂154.00Echelon/Neutral Sphingomyelinase Assay Service/10 SAMPLES/T-1800T-1800脂类663.00Echelon/PI3-K Beta Inhibitor Screening Service/60 Samples/T-1300B-4T-1300B-4脂质代谢研究3407.00Echelon/Cardiolipin Beads/100 UL/P-BCLPP-BCLP微球123.00Echelon/PI3-K Alpha Inhibitor Screening Service/40 SAMPLE/T-1300A-3T-1300A-3多肽2966.00Echelon/5′ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay/EA KIT/K-1400K-1400其它检测试剂盒557.00echelon-inc/Sphingosine 1-Phosphate ELISA Kit/1ea/K-1900-1eaK-1900-1eaInhibitors夹心法ELISA1214.00