CatalogNo.: L-3000 CAS: 885331-21-5 Description: ThePLA2substrateDBPC,isasensitiveprobeforacontinuousfluorogenicdetectionapplicabletoboth/invitro/andcell-based/insitu/screeningassays
PhospholipaseA2(PLA2)istheenzymewhichcleavesphospholipidstoproducelysophospholipidsandfreefattyacids.ThePLA2familyofenzymesisknowntobeatleast10distinctmembers.sPLA2-VandsPLA2-XareselectivelyexpressedinhumanairwayepitheliumandsPLA2-Xinvariousimmunecells.Thebasalexpressionofathirdenzyme,sPLA2-IIAislowbutbecomeshighlyexpressedduringinflammationandsepsis.Thisenzymehasbecomeassociatedwithallergicrhinitis,rheumatoidarthritis,septicshockandARDS.PLA2-IIArepresentsatargetforthetreatmentofinflammatorydisease. Storage -20°Cprotectedfromlight FeaturedinPublications 1)Zhao,X.,D.Wang,etal.(2006)."Caspase-3-dependentactivationofcalcium-independentphospholipaseA2enhancescellmigrationinnon-apoptoticovariancancercells."JBiolChem281(39):29357-68. 2)Manna,D.,W.Cho,etal.(2007).Real-TimeCellAssaysofPhospholipaseA2sUsingFluorogenicPhospholipids.MethodsinEnzymology,AcademicPress.Volume434:15. 3)Cai,Q.,Z.Zhao,etal.(2012)."ElevatedandsecretedphospholipaseA2activitiesasnewpotentialtherapeutictargetsinhumanepithelialovariancancer."TheFASEBJournal26(8):3306-3320. Keywords:DBPC,Bodipy,PLA2,phospholipase

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