BrP-LPA, aka LPA bromophosphonate, acts as both an Autotaxin inhibitor (94% inhibition at 10 μM) and pan LPA receptor antagonist (LPA₁: 1.5 μM, LPA₂: 1.4 μM, LPA₃: 1.2 μM, LPA₄: 0.27 μM). BrP-LPA inhibits the invasiveness of NIH3T3 ras ATX cells by 40% and decreases chemotaxis by 23%. BrP-LPA reduces the size of breast (MDA-MB-231), colon (HCT-116) and melanoma (B16F10) tumors in mouse models. It also attenuates collagen-induced arthritis PPARγ is not activated by BrP-LPA.

---

Publications

1) Jiang, G., Y. Xu, et al. (2007). “Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA.” ChemMedChem 2(5): 679-90.2) Zhang, H., X. Xu, et al. (2009). “Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo.” Cancer Res 69: 54413) Schleicher, S. M., D. K. Thotala, et al. (2011). “Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature.” PLoS ONE 6(7): e22182.4) Nikitopoulou, I., E. Kaffe, et al. (2013). “A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis.” PLoS ONE 8(7): e70941

Categories	Biochemical Reagents
Filter	Autotaxin, Inhibitor, Lysophosphatidic Acid
CAS Number	944265-88-7
Molecular Formula	C20H39BrNaO6P
Molecular Weight (g/mol)	509.4
Purity	95%
Storage	-20 °C or below

Echelon常用产品报价单产品名货号公司分类商城分类美金价Echelon/Anti-Rat F1-ATP Synthase Alpha Subunit Rabbit Polyclonal Antibody/100 UL/Z-RATPAZ-RATPA功能性抗体400.00Echelon/Biotinylated Anti-PtdIns(3,4)P2 IgG/50 UG/Z-B034Z-B034其它重组蛋白586.00Echelon/Goat anti-human Autotaxin antibody/10 UG/Z-P400Z-P400抗人83.00Echelon/PI4-Kinase beta (PI4Kb), active/5 UG/P32-102GP32-102G激酶226.00Echelon/1-Methylhistamine dihydrochloride/25 MG/B-0032B-0032其他试剂154.00Echelon/Neutral Sphingomyelinase Assay Service/10 SAMPLES/T-1800T-1800脂类663.00Echelon/PI3-K Beta Inhibitor Screening Service/60 Samples/T-1300B-4T-1300B-4脂质代谢研究3407.00Echelon/Cardiolipin Beads/100 UL/P-BCLPP-BCLP微球123.00Echelon/PI3-K Alpha Inhibitor Screening Service/40 SAMPLE/T-1300A-3T-1300A-3多肽2966.00Echelon/5′ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay/EA KIT/K-1400K-1400其它检测试剂盒557.00echelon-inc/Sphingosine 1-Phosphate ELISA Kit/1ea/K-1900-1eaK-1900-1eaInhibitors夹心法ELISA1214.00