CatalogNo.: B-0302 MW: 287.2 Purity: 99% CAS: 648449-76-7 Description: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione(AS604850)isaninhibitorofPI3- KγwithanIC50=250nM.AS604850isselectivefortheγ-isoform(IC50:PI3-Kα=4.5μM,PI3-Kβ,PI3-Kδ>20μM)and showsnonotableactivityagainstawidearrayofproteinkinasesat1μM.
Solubility water:insoluble,DMSO:5mg/mL Storage storedrybetween2-8oC.Stocksolutionsshouldbestoredfrozen(-20oC). References 1)M.Campsetal.“BlockadeofPI3Kgsuppressesjointinflammationanddamageinmousemodelsof rheumatoidarthritis”NatureMedicine,2005,11,936-943.

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