Human CD34 is an unusual glycosylated membrane protein exclusively expressed on immature hematopoietic cells and on endothelial cells. CD34 may have a role in cell adhesion. CD34 has extensive utility for bone marrow transplantation (3, 4).

Isotype: Murine IgG3 kappa

Immunogen: Human KG-1a tumor cells

Specificity: Antibody 43A1 recognizes the class II epitope of the 110 kd CD34 molecule (1, 2,) which is resistant to neuraminidase and sensitive to glycoprotease (6).

References:

1. H.J. Bühring, et al, (1991) Leukemia 5: 854-860.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 840-874.

3. R.H. Collins, (1994) Stem Cells 12: 577-585.

4. T.L. Holyoake & M.J. Alcorn, (1994) Blood Reviews 8: 113-124.

5. J.P. Levesque, L.J. Bendell, et al. (2003) J Clin Invest 110: 187-196.

6. Lanza R, Sutherland DR, et al. (2001) J Biol Regulators and Homeostatic Agents 15:1-13.

7. M Vigano, de Girolamo, et al. (Feb 2017) J Exp Orthopaedics 4: 8.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。