The human CD1 genetic locus consists of five closely related genes (1). Three of the gene products (CD1a, CD1b and CD1c) have been officially clustered using antibodies and are expressed on cortical thymocytes, a subset of B cells, and on most professional antigen presenting cells (2). CD1a⁺/CD11c⁺ dendritic cells are direct precursors of Langerhans cells in peripheral blood (4). CD1 molecules have a specialized lipid antigen-presenting function (3)..

Isotype: Murine IgG1kappa

Immunogen: Human Jurkat tumor cells

Specificity:Antibody CB-T6 recognizes the CD1a molecule of about 49 kd.

References:

1. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 33-37.

2.Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 337-341.

3. E.M. Beckman, et al, (1994) Nature 372: 691-694.

4.T. Ito, et al, (1999) J Immunol 163: 1409-1419.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。