Human CD15 is expressed by neutrophils, eosinophils and monocytes. Antibodies in this cluster recognize a common terminal pentasaccharide found on cell surface glycoproteins and glycolipids.

Isotype: Murine IgM

Immunogen: Human neutrophils

Specificity: Antibody AHN1.1 reacts with an extracellular epitope of the human terminal pentasaccharide lacto-N-fucopentaose III known as Lewis X (1, 3).

Functional Application: Antibody AHN1.1 activates normal monocytes and inhibits neutrophil chemotaxis.

References:

1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989)p. 798-810.

2. M.A. Kerr & S.C. Stocks, (1992) Histochem J 24: 811-826.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 790-800.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。