Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets, and basophils (1). CD17 expression is downmodulated on activated granulocytes. CD17 is an important componant in CD11b/CD18 mediated phagocytosis of microbes (2).

Isotype: Murine IgM

Immunogen: Human beta-2 microglobulin associated proteins from a detergent lysate of PBL

Specificity: Antibody Huly-m13 requires CD17 on human myeloid cells. It does not recognize mouse LacCer (6).

References:

1. Leukocyte Typing IV (W Knapp, et al, eds.) Oxford University Press, Oxford (1989) p. 877-879.

2. Nakayama H, K Iwabuchi, et al. (2008) J Leukocyte Biol 83:728-741.

3. Rusciani A, Duca L, Sartelet H, Chatron-Colliet A, Bobichon H, et al. (2010)PLoS ONE 5(11): e14010.

4. Chatterjee S, Alsaeedi N, Hou J, Bandaru VVR, Wu L, et al. (2013) PLoS ONE 8(5): e63726.

5. Hulkova H, M Elleder, et al. (2005) Virchows Archiv 447(1): 31-44.

6. K Iwabuchi, K Takamori, et al. (2015) Glycobiology 25(6): 655-68. PMID: 25595946

7. H Nakamura, T Murayama, et al. (2017) J cell Biol 118(12): 4370-4382. PMID:2844490DOI:10.1002/jcb.26091

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。