The human CD3/T cell receptor (TcR) complex is made up of at least five CD3 proteins (gamma, delta, epsilon, h, z) in association with either alpha/beta or gamma/delta proteins of the TcR (2). The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells. e.

Isotype: Murine IgG1

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHT1 recognizes the 20 kd epsilon chain (3) of the CD3 molecule complex (1, 2).

Functional Application: Antibody UCHT1 will activate T cells expressing CD3(6)

References:

1. P.C.L. Beverly & R.E. Callard, (1981) Eur J Immunol 11: 329-334.

2. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 290-314.

3. A. Salmeron, et al, (1991) J Immunol 147: 3047-3052.

4. G. Thibault & P. Bardos, (1995) J Immunol 154: 3814-3820.

5. VanDongen JJ, C Terhorst, et al. (1988) Blood 71(3):603-12.

6. S Velasquez. CM Alvarez, et al. (2016) Human Immunol 77(5): 403-410. https://doi.org/10.1016/j.humimm.2016.03.004

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。