Human CD21 is a receptor for complement fragments C3d, C3dg or ic3D (1, 5) and also EBV (4). CD21 is also a ligand for CD23 and plays a role in IgE synthesis (3).

Isotype: Murine IgG1

Immunogen: Human HFB-1 cell line

Specificity: Antibody BU33 recognizes the CD21 molecule of about 145 kd (1). BU33 has been shown to bind to Equine B cells, suggesting cross reactivity (7).

Functional Application: Antibody BU33 inhibits the CD21 - CD23 interaction (2, 6, 8).

References:

1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 516-523.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 535-538.

3. J.Y. Bonnefoy, et al, (1995) Intl Archiv Allergy Immunol 107: 40-42.

4. A.D. Beaulieu, et al, (1995) Blood 86: 2789-2798.

5. H. Molina, et al, (1995) J Immunol 154: 5426-5435.

6. S Henchoz, J Y Bonnefoy, et al. (1994) Immunology 81(2): 285-290.

7. S. Mayall, Hamblin A.S., et al. (2001) J Comp Pathol 124(1): 83-87.

8. S Henchoz, J Y Bonnefoy, et al. (1996) Immunolgy 88: 35-39.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。