Immunogen: Activated human NK cells

Isotype: Murine IgG2b

Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells. CD161 has been implicated in the regulation of NK cell mediated cytotoxicity. CD161 positive TH17 cells are resistant to Treg mediated suppression.(5).

Antibody B199.2 recognizes the dimeric 160 kd CD161 molecule.

Functional Application: In MLR, blockade with antibody B199.2 caused a slight but significant reduction in the percentage of IFN gamma-expressing NK cells challenged with M. tuberculosis (4).

References:

1) I.M. Bennett, et al, (1996) J Exp Med 184: 1845-1856.

2)L. Azzoni, et al, (1998) J Immunol 161: 3493-3500.

3) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 307-317.

4) Schierloh P, MC Sasiain, et al. (2007) Infection and Immunity 75(11): 5325-5337.

5) S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540. PMID 26062995.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。