Human CD100 is a transmembrane glycoprotein that belongs to the semaphorin gene family and is found on most hematopoietic cells except RBC, platelets and immature bone marrow cells. CD100 plays a key role in lymphocyte activation (2, 3). Interaction of CD100 with its ligand CD72 has implications in the mechanism of NK cell killing (4).

Isotype: Murine IgM

Immunogen: PHA stimulated human PBL

Specificity: Antibody 133-1C6 recognizes an extracellular epitope of the human CD100 molecule of about 150 kd.

References:

1.) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 534-539.

2.) K.T. Hall, et al, (1996) Proc Natl Acad Sci USA 93:11780-11785.

3.) A. Elhabazi, et al, (1997) J Biol Chem 272: 23515-23520.

4.) S. Mizrahi, O Mandelboim, et al.(2007) PLoS ONE 2(9):e818.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。