Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation (3). CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily (1,2). CD137 appears to be important for T cell proliferation and survival (4) and induces monocyte activation (5).

Isotype: Murine IgG1 kappa

Immunogen: Ectodomain of recombinant human 4-1BB fusion protein

Specificity: Antibody 4B4-1 recognizes an extracellular epiopte of the human CD137 molecule of about 35 kd on activated T cells (3).

Functional Application: Antibody 4B4-1 blocks binding of CD137 huIg to Raji cells. Immobilized mAb has been shown to induce TNF a production by monocytes(6) and IFNg production by NK cells(7).

References:

1. M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227.

2. H.J. Gruss, and S.K. Dower, (1995) Blood 85: 3378-3404.

3. B.A. Garni-Wagner, et al, (1996) Cellular Immunol 169: 91-98.

4. H. Schwarz, et al, (1996) Blood 87: 2839-2845.

5. J. Langstein, H. Schwartz, et al, (1998) J Immunol 160: 2488-2494.

6. G. Kienzle, J. von Kempis, (1999) Int Immunol 12(1): 73-82.

7. Baessler T, H R Salih, et al. (2009) 115(15): 3058-3069.

Ancell抗CD105异花青素人CD105（endoglin）是一种同型二聚体膜糖蛋白（1），实际上局限于内皮细胞，并且存在于一些白血病细胞和少量骨髓细胞中。CD105 以高亲和力与TGF- b 1和b 3结合（4）。同种型：鼠IgG1 kappa免疫原：人B谱系白血病细胞的膜制备特异性：抗体SN6识别分子量约为160 kd的人CD105同型二聚体的细胞外表位。据报道它与非人类灵长类动物以及马和猪（11）CD105发生交叉反应。功能应用：抗体SN6将增强TGF-b1与表达CD105的白血病细胞的结合。  抗体SN6已用于鉴定间充质祖细胞群（8,9,10）。