DescriptionSequence(One-Letter Code)

Product Name	Protease - Activated Receptor - 4, PAR - 4 Agonist, amideAYPGKF - NH2
Size	5 mg
Catalog #	AS-60218-5
US$	$272
Purity	% Peak Area By HPLC ≥ 95%
PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
Detailed Information	Datasheet Material Safety Data Sheets (MSDS)
Storage	-20°C
References	Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005).
Molecular Weight	680.8
AYPGKF-NH2
Sequence(Three-Letter Code)	H - Ala - Tyr - Pro - Gly - Lys - Phe - NH2
Product Citations	Naik, M.U. et al. (2009). CIB1 deficiency results in impaired thrombosis: the potential role of CIB1 in outside-in signaling through integrin αIIbβ3 J Thrombosis Haemostasis 7 doi: 10.1111/j.1538-7836.2009.03581.x.Lindsey, S. et al. (2014). Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling J Thrombosis Haemostasis 12 doi: 10.1111/jth.12490. Naik, M. U. et al. (2012). JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets blood119 doi: 10.1182/blood-2011-12-397398. Patil, S.B. et al. (2010). Ticagrelor effectively and reversibly blocks murine platelet P2Y12-mediated thrombosis and demonstrates a requirement for sustained P2Y12 inhibition to prevent subsequent neointima Am Heart Assoc doi: 10.1161/ATVBAHA.110.210732.Panicot-Dubois, L. et al. (2007). Bile salt–dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans J Clinical Invest doi:10.1172/JCI32655. Erhard, J.A. et al. (2006). P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation J Thrombosis Haemostasis4 doi: 10.1111/j.1538-7836.2006.01849.x. Rauch, B. H. et al. (2003) Thrombin- and factor Xa–Induced DNA synthesis Is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells Am Heart Assoc doi: 10.1161/01.RES.0000111805.09592.D8. Murad, JP. et al. (2012). Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan J Cardiovasc Pharmacol Ther 17 308. doi: 10.1177/1074248411425491.Su, X. et al.(2005) Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms 1J Immunol 175 doi: 10.4049/​jimmunol.175.4.2598.Kataoka, H. et al. (2003). Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells Blood 102 doi: 10.1182/blood-2003-04-1130.

Anaspec在过去的二十年中，荧光检测生理学和神经学信号受到了极大的关注。使用分子荧光或发光来感测生理和神经信号具有若干优点。其中包括高灵敏度（低至单个分子），开-关切换性，活细胞通信的可行性，具有亚微米可视化的亚纳米空间分辨率和亚毫秒级时间分辨率。光诱导电子转移（PET）和电子能量转移（EET）主要用于将离散的和化学计量的识别事件转换为荧光信号。基于PET效应，开发了许多荧光生理指示剂（如下所述）。AnaSpec提供高质量和具有竞争力的价格的多种生理和神经指标（例如Fura-2，Indo-1和Rhod-2），用于各种生物学应用。AnaSpec努力提供可在任何地方使用的最高纯度的指标。通过HPLC分析，我们的UltraPure级AM荧光指示剂酯的纯度通常至少为95％，尽管纯度通常超过98％。此外，我们还为您提供许多Ca2 +指示剂的AM酯的定制包装服务，以最小的费用为您提供便利，并降低了存储期间变质的风险。