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商品描述
| Other Names | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit IV isoform 1, COX IV-1, Cox4i1, Cox4, Cox4a |
|---|---|
| Target/Specificity | This COX IV antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 115-169 amino acids from the mouse region of human COX IV. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Application | WB : 1:1000 - 1:2000 |
| FC : 1:25 - 1:50 |
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gendepot在脊椎动物中，已经鉴定出3个主要的肌动蛋白同种型，即α，β和γ。α肌动蛋白存在于肌肉组织中，是收缩装置的主要组成部分。在大多数细胞类型中，β和γ肌动蛋白作为细胞骨架的成分和内部细胞运动的介质共存。β肌动蛋白是高度保守的蛋白，参与细胞运动，结构和完整性。β肌动蛋白是细胞质蛋白。抗肌动蛋白是一种上样对照抗体，对于正确理解您的蛋白质印迹至关重要。β-肌动蛋白加载控制抗体用于通过确认整个凝胶上的蛋白加载均匀来标准化检测到的蛋白水平。 参考文献（0） 
