ThebafilomycinsareafamilyofmacrolideantibioticderivedfromStreptomycesgriseus.ThesecompoundsallappearinthesamefermentationandhavequitesimilarBIOLOGicalactivity.Bafilomycinsarespecificinhibitorsofvacuolar-typeH+-ATPase.ThemostusedbafilomycinisbafilomycinA1. Thisisausefultoolasitcanpreventthere-acidificationofsynapticvesiclesoncetheyhaveundergoneexocytosis.Bafilomycinhasantibacterial,antifungal,antineoplastic,immuno-suppressiveactivities.Inaddition,bafilomycinA1hasantimalarialactivity.Ithasbeenshowntodecreasemulti-drugresistance.BafilomycinB1hasbeenmentionedasapotentialantioseoporoticagentintreatingbonelyticdiseases.
