Calmodulin (CaM) is a ubiquitous, calcium-binding protein that binds and regulates a multitude of protein targets, many of which are involved in the Alzheimer"s and the Parkinson"s pathways^1,4. CaM has a molecular weight of about 17kDa, containing 148 amino acids, and pI of 3.9. CaM is characterized by two domains, connected by an alpha-helix chain. Each domain has the capacity to bind two calcium ions. Binding Ca²⁺ ions causes a conformational change in CaM, making it available for interaction with target proteins. Hence, CaM functions as an intracellular calcium ion bridge to mediate cellular reactions and responds appropriately to calcium ion concentration. In Alzheimer"s disease (AD), irregular calcium homeostasis seems to trigger CaM and its binding proteins, to enhance plaque formation and neurofibrillary degeneration, which results in cell death1. The increased cytosolic levels of Ca²⁺ in AD neurons promotes CaM binding and regulation of available Ca²⁺/CaM-dependent CaM-binding proteins, associated with amyloid beta (Ab) formation. In addition, the increased level of Ca²⁺ triggers Calmodulin to activate calcium/CaM-dependent kinase II and precede neurofibrillary tangle formation^2,4. In Parkinson"s disease (PD), Calmodulin has been found to interact, in a calcium dependent manner, with Alpha-Synuclein, which is associated with the progression of PD. CaM was identified as one of the synuclein-interacting proteins that regulate synuclein conformation³. rPeptide is a biotechnology company providing a range of research products and services, with a focus on products for Alzheimer\'s and Parkinson\'s disease research. 阿尔茨海默氏症及帕金森症相关产品       货号 品名 包装 报价 品牌 A-1001-1 Beta-Amyloid （1-40）, Ultra Pure, TFA 0.5 mg 2040 rpeptide A-1001-2 Beta-Amyloid （1-40）, Ultra Pure, TFA 1.0 mg 3400 rpeptide A-1002-1 Beta-Amyloid （1-42）, Ultra Pure, TFA 0.5 mg 2975 rpeptide A-1002-2 Beta-Amyloid （1-42）, Ultra Pure, TFA 1.0 mg 5100 rpeptide A-1003-1 Beta-Amyloid （1-40, Scrambled） 0.5 mg 2550 rpeptide A-1003-2 Beta-Amyloid （1-40, Scrambled） 1.0 mg 4675 rpeptide A-1004-1 Beta-Amyloid （1-42, Scrambled） 0.5 mg 3740 rpeptide A-1004-2 Beta-Amyloid （1-42, Scrambled） 1.0 mg 5950 rpeptide A-1005-1 Beta-Amyloid （1-43）, Ultra Pure, TFA 0.5 mg 3740 rpeptide A-1005-2 Beta-Amyloid （1-43）, Ultra Pure, TFA 1.0 mg 6375 rpeptide A-1007-1 Beta-Amyloid （1-40）, Mouse, Rat  0.5 mg 3825 rpeptide A-1008-1 Beta-Amyloid （1-42）, Mouse, Rat  0.5 mg 4845 rpeptide A-1011-1 Beta-Amyloid （1-40, F4W） 100 ug 1530 rpeptide A-1011-2 Beta-Amyloid （1-40, F4W） 1.0 mg 8075 rpeptide A-1012-1 Beta-Amyloid （1-40, Y10W） 100 ug 1530 rpeptide A-1012-2 Beta-Amyloid （1-40, Y10W） 1.0 mg 8075 rpeptide A-1013-1 Beta-Amyloid （1-40, D23N） 100 ug 1530 rpeptide A-1013-2 Beta-Amyloid （1-40, D23N） 1.0 mg 8075 rpeptide A-1021-1 Beta-Amyloid （1-42, M35V） 100 ug 1700 rpeptide A-1021-2 Beta-Amyloid （1-42, M35V） 1.0 mg 9775 rpeptide A-1022-1 Beta-Amyloid （1-42, R5G） 100 ug 1700 rpeptide A-1022-2 Beta-Amyloid （1-42, R5G） 1.0 mg 9775 rpeptide A-1023-1 Beta-Amyloid （1-42, Y10A） 100 ug 1700 rpeptide A-1023-2 Beta-Amyloid （1-42, Y10A） 1.0 mg 9775 rpeptide A-1024-1 Beta-Amyloid （1-42, F4W） 100 ug 1700 rpeptide A-1024-2 Beta-Amyloid （1-42, F4W） 1.0 mg 9775 rpeptide A-1025-1 Beta-Amyloid （1-42, H6A） 100 ug 1700 rpeptide A-1025-2 Beta-Amyloid （1-42, H6A） 1.0 mg 9775 rpeptide A-1026-1 Beta-Amyloid （1-42, H13A） 100 ug 1700 rpeptide A-1026-2 Beta-Amyloid （1-42, H13A） 1.0 mg 9775 rpeptide A-1027-2 Beta-Amyloid （1-42, H14A） 1.0 mg 9775 rpeptide A-1051-1 Beta-Amyloid （1-11） 1 mg 1530 rpeptide A-1051-2 Beta-Amyloid （1-11） 5 mg 4760 rpeptide A-1052-1 Beta-Amyloid （1-16） 1 mg 1683 rpeptide A-1052-2 Beta-Amyloid （1-16） 5 mg 5440 rpeptide A-1053-1 Beta-Amyloid （1-28） 0.5 mg 1955 rpeptide A-1053-2 Beta-Amyloid （1-28） 1.0 mg 3145 rpeptide A-1055-1 Beta-Amyloid （11-22） 1 mg 1870 rpeptide