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商品描述
UbE3A(alsocalledE6AP)isa100kDaHECT(homologoustoE6APcarboxylterminus)domainubiquitinligasecontainingtwoE2bindingsitesforUbcH7andUbcH8.UbE3Awasfoundtobindtothehumanpapillomavirus(HPV)oncoproteinE6andmediateubiquitinationofp53.AframeshiftmutationintheUbE3AgeneleadstolossoffunctionandcausesAngelmanSyndrome.
AdditionalInformation
| ProductName: | UbE3A(E6AP) |
|---|---|
| AlsoKnownAs: | AS;ANCR;E6-AP;E6AP;HPVE6A;EPVE6AP |
| CatalogNo.: | K1411 |
| Size: | 50µg |
| MolecularWeight: | 100.7kDa |
| Species: | Human |
| Source: | Bacterialrecombinant |
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
| Concentration: | Seetubelabel |
| QualityAssurance: | ~90%bySDS-PAGE,seedatasheetforgelimage |
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
| PDFDataSheet: | PDFDatasheet |
| NCBIRefSeq: | NM_000462.3 |
| Image(s): | PleaseclickproductPDFdatasheetabovetoviewarepresentativeSDS-PAGEofUbE3A. |
| ShippingMethod: | Dryiceshipping |
| References: | 1.ScheffnerM,etal.(1990)Cell63,11291136. 2.ScheffnerM,etal.(1993)Cell75,495505.3.AbaiedL,etal.(2009)AmJMedGenetPartA152A,141146. 4.RonchiVP,etal.(2013)JBC288,1034910360. |
