品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
ITCH,alsocalledatrophin-1interactingprotein4(AIP4),isaHECT-typeE3ubiquitinligase.ItcontainsanN-terminalCa<>-dependentphospholipid-bindingC2domain,fourWWdomains,andaC-terminalHECTdomain.MicedeficientinITCHproteindisplaymanyautoimmune-likediseasecharacteristicssuchaslymphoproliferationinthespleenandlymphnodes.MorethanadozenofsubstratesofITCHhavebeenidentifiedincludingp63,p73andNotch1.TheligasemayberesponsIBLeforubiquitinatingproteinswithK29-,K48-,and/orK63-linkedubiquitinchains.
AdditionalInformation
| ProductName: | ITCH | ||
|---|---|---|---|
| AlsoKnownAs: | AIF4;AIP4;NAPP1;dJ468O1.1 | ||
| CatalogNo.: | K1400 | ||
| Size: | 50µg | ||
| MolecularWeight: | 102.8kDa | ||
| Species: | Human | ||
| Source: | Bacterialrecombinant | ||
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol | ||
| Concentration: | Seetubelabel | ||
| QualityAssurance: | ~90%bySDS-PAGE,seedatasheetforgelimage | ||
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles | ||
| PDFDataSheet: | PDFDatasheet，MSDS | ||
| NCBIRefSeq: | NM_001257137 | ||
| Image(s): | (Clickimagetoenlarge)
| ||
| ShippingMethod: | Dryiceshipping | ||
| References: | 1.PerryWL,etal.(1998)NatGenet18,143–146. 2.SchwarzSE,etal.(1998)JBiolChem273,12148–12154.3.MelinoG,etal.(2008)CellDeathDiffer15(7),1103–1112. |
 |
| Coomassie-stainedSDS-PAGE Lane1:Molecularweightmarkers Lane2:5µgpurifiedITCH |
