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商品描述
HSP70acriticalchaperoneproteinthathasahighaffinityforunfoldedpolypeptidechains.Itbindsextendedpeptidesegmentswithanethydrophobiccharacterexposedbypolypeptidesduringtranslationandmembranetranslocation,orfollowingstress-induceddamage.Incooperationwithotherchaperones,Hsp70stABIlizespreexistentproteinsagainstaggregationandmediatesthefoldingofnewlytranslatedpolypeptidesinthecytosolaswellaswithinorganelles.Hsp70andHsp40recruitsomemisfoldedproteinstotheubiquitinE3ligaseCHIPforubiquitination.
AdditionalInformation
| ProductName: | HSP70 |
|---|---|
| AlsoKnownAs: | HSPA1A;HSP72;HSPA1;HSP70I;HSP70-1;HSP70-1A |
| CatalogNo.: | K1300 |
| Size: | 25µg |
| MolecularWeight: | 70kDa |
| Species: | Human |
| Source: | Bacterialrecombinant |
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol |
| Concentration: | Seetubelabel |
| QualityAssurance: | ~90%bySDS-PAGE,seedatasheetforgelimage |
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles |
| PDFDataSheet: | PDFDatasheet，MSDS |
| NCBIRefSeq: | NM_005345 |
| Image(s): | N/A |
| ShippingMethod: | Dryiceshipping |
| References: | 1.Walerych.,etal.(2009)Oncogene28:4284-94 2.DaugaardM,etal.(2007)FEBSLett.581:3702-37103.KluckenJ,etal.(2006)FASEBJ.20,2050 4.FreemanBC,etal.(1995)EMBOJ14:2281-22-92 |
