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商品描述
ThecarboxylterminusofHsc70-interactingprotein(CHIP)isanE3ubiquitinligase.CHIPcontainstwodomains,oneisitsTPRdomainontheaminoterminusandtheotherisitsU-boxdomainonthecarboxylterminus.TheTPRdomainrecognizesthechaperones,Hsp70andHsp90.WhiletheU-boxdomaincarriesoutitsubiquitinligaseactivity.CHIPoftenubiquitinatesmisfoldedproteinsboundonthechaperones.
AdditionalInformation
| ProductName: | 6xHis-CHIP | ||
|---|---|---|---|
| AlsoKnownAs: | STUB1;UBOX1;HSPABP2;NY-CO-7;SDCCAG7 | ||
| CatalogNo.: | K1200 | ||
| Size: | 50µg | ||
| MolecularWeight: | 34.9kDa | ||
| Species: | Human | ||
| Source: | Bacterialrecombinant | ||
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol | ||
| Concentration: | Seetubelabel | ||
| QualityAssurance: | ~95%bySDS-PAGE,seedatasheetforgelimage | ||
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles | ||
| PDFDataSheet: | PDFDatasheet，MSDS | ||
| NCBIRefSeq: | NM_005861 | ||
| Image(s): | (Clickimagetoenlarge)
| ||
| ShippingMethod: | Dryiceshipping | ||
| References: | 1.BallingerCA,etal.(1999)MolCellBiol19(6),4535–4545. 2.MurataS,etal.(2003)IntJBiochemCellBiol35(5),572–578. |
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| Coomassie-stainedSDS-PAGE Lane1:Molecularweightmarkers Lane2:5µgpurified6xHis-CHIP |
