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苏州工业园区生物纳米园A4#216
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商品描述
APPBP1/UBA3istheheterodimericE1enzymethatconjugatesNedd8toproteinsubstrates.Nedd8isconjugatedontothecatalyticcysteineresidueofUBA3byformationofathioesterbondinanATP-dependentreaction.TheactivatedNedd8isthenpassedontoanE2(Ubc12)tobefinallyattachedtoasubstrate.Nedd8ismainlyconjugatedonCullinstoincreasetheactivityoftheCullin–RINGE3Ubligases.
AdditionalInformation
| ProductName: | APPBP1/6xHis-UBA3 | ||
|---|---|---|---|
| AlsoKnownAs: | APPBP1(NAE1;HPP1;ula-1;A-116A10.1);UBA3(UBE1C;hUBA3;MGC22384;DKFZp566J164) | ||
| CatalogNo.: | B1401 | ||
| Size: | 100µg | ||
| MolecularWeight: | APPBP1(60.2kDa),UBA(51.8kDa) | ||
| Species: | Human | ||
| Source: | Bacterialrecombinant | ||
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol | ||
| Concentration: | Seetubelabel | ||
| QualityAssurance: | ~95%bySDS-PAGE,seedatasheetforgelimage | ||
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles | ||
| PDFDataSheet: | PDFDatasheet，MSDS | ||
| NCBIRefSeq: | NM_003905(APPBP1);NM_003968(UBA3) | ||
| Image(s): | (Clickimagetoenlarge)
| ||
| ShippingMethod: | Dryiceshipping | ||
| References: | 1.WhitbyFG,etal.(1998)JBiolChem273(52),34983–34991. 2.OsakaF,etal.(1998)GenesDev12(15),2263–2268.3.WaldenH,etal.(2003)MolCell12(6),1427–1437. 4.SchulmanBA,etal.(2009)NatRevMolBiol10(5),319–331. |
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| Coomassie-stainedSDS-PAGE Lane1:Molecularweightmarkers Lane2:5µgpurifiedAPPBP1/6xHis-UBA3 |
