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商品描述
SAE1/SAE2istheheterodimericE1enzymethatconjugatesSUMOtoproteinsubstrates.Theconjugationprocessisverysimilartothatofproteinubiquitination.SUMOisconjugatedontothecatalyticcysteineresidueofSAE2byformationofathioesterbondinanATP-dependentreaction.TheactivatedSUMOisthenpassedontoanE2(Ubc9)tobefinallyattachedtoasubstrate.
AdditionalInformation
| ProductName: | 6xHis-SAE1/SAE2 | ||
|---|---|---|---|
| AlsoKnownAs: | SAE1(AOS1;SUA1;UBLE1A;HSPC140;FLJ3091);SAE2(RBBP8;RIM;CTIP;JWDS;SCKL2) | ||
| CatalogNo.: | B1301 | ||
| Size: | 100µg | ||
| MolecularWeight: | SAE1(33kDa),SAE2(71.2kDa) | ||
| Species: | Human | ||
| Source: | Bacterialrecombinant | ||
| Stock: | 20mMTris,150mMNaCl,2mMβME,10%Glycerol | ||
| Concentration: | Seetubelabel | ||
| QualityAssurance: | ~95%bySDS-PAGE,seedatasheetforgelimage | ||
| Storage: | Storeat-80°C;avoidmultiplefreeze-thawcycles | ||
| PDFDataSheet: | PDFDatasheet，MSDS | ||
| NCBIRefSeq: | NM_005500(SAE1);NM_002894(SAE2) | ||
| Image(s): | (Clickimagetoenlarge)
| ||
| ShippingMethod: | Dryiceshipping | ||
| References: | 1.DesterroJM,etal.(1999)JBiolChem274(15),10618–10624. 2.MelchiorF(2000)AnnuRevCellDevBiol16,591–626.3.SchulmanBA,etal.(2009)NatRevMolBiol10(5),319–331. |
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| Coomassie-stainedSDS-PAGE Lane1:Molecularweightmarkers Lane2:5µgpurified6xHis-SAE1/SAE2 |
