Prosci/Betacellulin重组蛋白/40-578/0.02mg

价格
¥4500.00
货号:40-578
浏览量:127
品牌:ProSci
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商品描述

Specifications

SPECIES:Murine
SOURCESPECIES:E.coli
SEQUENCE:DGNTTRTPETNGSLCGAPGENCTGTTPRQKVKTHFSRCPKQYKHYCIHGRCRFVVDEQTPSCICEKGYFGARCERVDLFY
TESTEDAPPLICATIONS:
BIOLOGICALACTIVITY:BiologicalactivitywasdeterminedbyitsABIlitytostimulatetheproliferationofmouseBalb/3T3cells.TheexpectedED50is≤0.01ng/mL,correspondingtoaspecificactivityof≥1x108units/mg.Endotoxinlevelislessthan0.1ngperμg(1EU/μg).

Properties

PURITY:Greaterthan98%bySDS-PAGEgelandHPLCanalyses.
PHYSICALSTATE:Lyophilized
STORAGECONDITIONS:ThelyophilizedBetacellulinrecombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedBetacellulinstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingBetacellulinrecombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature.

AdditionalInfo

ALTERNATENAMES:Bcn,Bcn,Probetacellulin,BTC
ACCESSIONNO.:NP_031594.1
PROTEINGINO.:6680812

Background

BetacellulinisanEGF-relatedpolypeptidegrowthfactorthatsignalsthroughtheEGFreceptor.Itisproducedinseveraltissues,includingthepancreas,smallintestine,andincertaintumorcells.Betacellulinisapotentmitogenforretinalpigmentepithelialcellsandvascularsmoothmusclecells.Betacellulinisinitiallysynthesizedasaglycosylated32.0kDatransmembraneprecursorprotein,whichisprocessedbyproteolyticcleavagetoproducethematuresequence.RecombinantmurineBetacellulinisa9.0kDamonomericprotein,containing80aminoresidues,whichcomprisesthematureEGFhomologousportionoftheBetacellulinprotein.
ProSci 研究计划包括癌症生物标记物发现和中和针对新兴病毒(例如HIV和流感)的抗体开发。ProSci的创新方法研究使用基因工程酵母菌株和糖蛋白模拟HIV-1聚糖衣壳并开发针对HIV-1聚糖的中和抗体,已获得NIH的多项小型企业创新研究(SBIR)资助。其研究项目已获得美国专利商标局授予的发明专利,以及许多同行评审的出版物