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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIESREACTIVITY: | Human,Mouse,Rat |
|---|---|
| TESTEDAPPLICATIONS: | ELISA,WB |
| APPLICATIONS: | ABCD4antibodycanbeusedfordetectionofABCD4byELISAat1:312500.ABCD4antibodycanbeusedfordetectionofABCD4bywesternblotat1μg/mL,andHRPconjugatedsecondaryantibodyshouldbediluted1:50,000-100,000. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher. |
| POSITIVECONTROL: | 1)721_BCellLysate |
| PREDICTEDMOLECULARWEIGHT: | 68kDa |
| IMMUNOGEN: | AntibodyproducedinrabbitsimmunizedwithasyntheticpeptidecorrespondingaregionofhumanABCD4. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | Antibodyispurifiedbypeptideaffinitychromatographymethod. |
|---|---|
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | AntibodyislyophilizedinPBSbufferwith2%sucrose.Add50μLofdistilledwater.Finalantibodyconcentrationis1mg/mL. |
| CONCENTRATION: | 1mg/ml |
| STORAGECONDITIONS: | Forshortperiodsofstorage(days)storeat4˚C.Forlongerperiodsofstorage,storeABCD4antibodyat-20˚C.Aswithanyantibodyavoidrepeatfreeze-thawcycles. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | ABCD4,ABC41,EST352188,P70R,P79R,PMP69,PXMP1L,MAHCJ |
|---|---|
| ACCESSIONNO.: | NP_005041 |
| PROTEINGINO.: | 4826958 |
| OFFICIALSYMBOL: | ABCD4 |
| GENEID: | 5826 |
Background
| BACKGROUND: | ABCD4isamemberofthesuperfamilyofATP-bindingcassette(ABC)transporters.ABCproteinstransportvariousmoleculesacrossextra-andintra-cellularmembranes.ABCgenesaredividedintosevendistinctsubfamilies(ABC1,MDR/TAP,MRP,ALD,OABP,GCN20,White).ThisproteinisamemberoftheALDsubfamily,whichisinvolvedinperoxisomalimportoffattyacidsand/orfattyacyl-CoAsintheorganelle.AllknownperoxisomalABCtransportersarehalftransporterswhichrequireapartnerhalftransportermoleculetoformafunctionalhomodimericorheterodimerictransporter.Thefunctionofthisperoxisomalmembraneproteinisunknown.However,itisspeculatedthatitmayfunctionasaheterodimerforanotherperoxisomalABCtransporterand,therefore,maymodifytheadrenoleukodystrophyphenotype.Itmayalsoplayaroleintheprocessofperoxisomebiogenesis.TheproteinencodedbythisgeneisamemberofthesuperfamilyofATP-bindingcassette(ABC)transporters.ABCproteinstransportvariousmoleculesacrossextra-andintra-cellularmembranes.ABCgenesaredividedintosevendistinctsubfamilies(ABC1,MDR/TAP,MRP,ALD,OABP,GCN20,White).ThisproteinisamemberoftheALDsubfamily,whichisinvolvedinperoxisomalimportoffattyacidsand/orfattyacyl-CoAsintheorganelle.AllknownperoxisomalABCtransportersarehalftransporterswhichrequireapartnerhalftransportermoleculetoformafunctionalhomodimericorheterodimerictransporter.Thefunctionofthisperoxisomalmembraneproteinisunknown.However,itisspeculatedthatitmayfunctionasaheterodimerforanotherperoxisomalABCtransporterand,therefore,maymodifytheadrenoleukodystrophyphenotype.Itmayalsoplayaroleintheprocessofperoxisomebiogenesis.Alternativesplicingresultsinatleasttwodifferenttranscriptvariants,onewhichisprotein-codingandonewhichisprobablynotprotein-coding. |
|---|---|
| REFERENCES: | 1)Asheuer,M.,(2005)Hum.Mol.Genet.14(10),1293-1303. |
