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- prosci incorporated |产品详情
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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIES: | Mouse |
|---|---|
| SOURCESPECIES: | HumanCells |
| SEQUENCE: | Asp23-Pro119 |
| FUSIONTAG: | C-Fctag |
| TESTEDAPPLICATIONS: | |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
| PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 38.1kD |
| PHYSICALSTATE: | Lyophilized |
| BUFFER: | Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
| STORAGECONDITIONS: | Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks. Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days. Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months. |
AdditionalInfo
| ALTERNATENAMES: | Serine/threonine-proteinkinasereceptorR3,SKR3,Activinreceptor-likekinase1,ALK-1,TGF-BsuperfamilyreceptortypeI,TSR-I,ACVRL1,activinAreceptortypeII-like1,activinAreceptor |
|---|---|
| ACCESSIONNO.: | Q61288 |
Background
| ActivinReceptor-LikeKinase1(ALK-1)isatypeIcell-surfacereceptorfortheTGF-betasuperfamilyofligands,whichmediatessignalingofBMP9(bonemorphogeneticprotein)andBMP10.ALK1signalingisnecessaryforangiogenesisduringembryogenesis,woundhealing,andtumorgrowth.ALK-1hasahighdegreeofsimilarityinserine-threoninekinasesuBDomains,aglycineandserinerichregionprecedingthekinase-domain,andaC-terminaltailwithotheractivinreceptor-likekinaseproteins.ALK-1ismainlyexpressedinendothelialcellsregulatingproliferationandmigrationinvitroandangiogenesisinvivo.MutationsinALK-1aswellasinendoglinareassociatedwithhereditaryhemorrhagictelangiectasia(HHT),suggestingALK-1playsacriticalroleforinthecontrolofbloodvesseldevelopmentorrepair. |
