Prosci/激活素A重组蛋白/40-213/0.01mg

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¥4500.00
货号:40-213
浏览量:127
品牌:ProSci
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Specifications

SPECIES:Human
SOURCESPECIES:E.coli
SEQUENCE:GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
TESTEDAPPLICATIONS:
BIOLOGICALACTIVITY:TheED50wasdeterminedbyitsABIlitytoinhibittheproliferationofmurineMPC-11cellsis≤2.0ng/mL,correspondingtoaspecificactivityof≥5x105units/mg.

Properties

PURITY:Greaterthan97%bySDS-PAGEgelandHPLCanalyses.

Endotoxinlevelislessthan0.1ngperμg(1EU/μg).
PHYSICALSTATE:Lyophilized
STORAGECONDITIONS:ThelyophilizedActivinArecombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedActivinAisstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingActivinArecombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature.

AdditionalInfo

ALTERNATENAMES:JV18,MADH2,MADR2,JV18-1,hMAD-2,hSMAD2,Mothersagainstdecapentaplegichomolog2,MADhomolog2
ACCESSIONNO.:NP_001003652.1
PROTEINGINO.:51173730

Background

ActivinAisaTGF-βfamilymemberthatexhibitsawiderangeofbiologicalactivitiesincludingregulationofcellularproliferationanddifferentiation,andpromotionofneuronalsurvival.ElevatedlevelsofActivinAinhumancolorectaltumorsandinpostmenopausalwomenhavebeenimplicatedincolorectalandbreastcancers,respectively.ThebiologicalactivitiesofActivinAcanbeneutralizedbyinhibinsandbythediffusIBLeTGF-βantagoNIST,follistatin.HumanActivinAisa26.0kDadisulfide-linkedhomodimeroftwoβAchains,eachcontaining116aminoacidresidues.
ProSci 研究计划包括癌症生物标记物发现和中和针对新兴病毒(例如HIV和流感)的抗体开发。ProSci的创新方法研究使用基因工程酵母菌株和糖蛋白模拟HIV-1聚糖衣壳并开发针对HIV-1聚糖的中和抗体,已获得NIH的多项小型企业创新研究(SBIR)资助。其研究项目已获得美国专利商标局授予的发明专利,以及许多同行评审的出版物