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蚂蚁淘在线 / 品牌中心 / ProSci / Prosci/Acrp30重组蛋白/40-326/0.005毫克

Prosci/Acrp30重组蛋白/40-326/0.005毫克

价格
￥3100.00
货号：40-326
浏览量：127
品牌：ProSci
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商品描述

Specifications

SPECIES:Human
SOURCESPECIES:E.coli
SEQUENCE:PGAEGPRGFPGIQGRKGEPGEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYFAYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGEGERNGLYADNDNDSTFTGFLLYHDTN
TESTEDAPPLICATIONS:
BIOLOGICALACTIVITY:BiologicalactivitywasdeterminedbyacytotoxicityassayusingM1cells.TheexpectedED50forthiseffectis0.5-1.0μg/mL.

Properties

PURITY:Greaterthan98%bySDS-PAGEgelandHPLCanalyses.

Endotoxinlevelislessthan0.1ngperμg(1EU/μg).
PHYSICALSTATE:Lyophilized
STORAGECONDITIONS:ThelyophilizedAcrp30recombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedAcrp30isstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingAcrp30recombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature.

AdditionalInfo

ALTERNATENAMES:ACDC,ADPN,APM1,APM-1,GBP28,ACRP30,ADIPQTL1,ACDC,Adiponectin,30kDaadipocytecomplement-relatedprotein
ACCESSIONNO.:NP_001171271.1
PROTEINGINO.:295317372

Background

ThegAcrp30variantisanaturallyoccurringglobularprotein,obtainedbyproteolyticprocessingofadiponectin.Adiponectinisproducedandsecretedexclusivelybyadipocytes,andisarelativelyabundantplasmaprotein,accountingforupto0.05%oftotalserumprotein.LikeAdiponectin,Acrp30iscapableofdecreasinghyperglycemiaandreversinginsulinresistance.Additionally,gAcrp30hasbeenshowntobeanimportantfactorinpromotingfatlossbysignalingmuscletoabsorbandburnFree-FattyAcids(FFAs).ThesignalingreceptorsforadiponectinandgAcrp30haverecentlybeenidentifiedandnamesAdipoR1andAdipoR2.AdipoR2ispredominantlyexpressedintheliver.ThisnaturallyoccurringvariantofhumangAcrp30/Adipoleanisan18.1kDaprotein,containing14aminoacidsextraattheN-terminusofhumangAcrp30/Adipolean.
ProSci 研究计划包括癌症生物标记物发现和中和针对新兴病毒（例如HIV和流感）的抗体开发。ProSci的创新方法研究使用基因工程酵母菌株和糖蛋白模拟HIV-1聚糖衣壳并开发针对HIV-1聚糖的中和抗体，已获得NIH的多项小型企业创新研究（SBIR）资助。其研究项目已获得美国专利商标局授予的发明专利，以及许多同行评审的出版物