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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIESREACTIVITY: | Human,Mouse,Rat |
|---|---|
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | Westernblot:1-3ug/ml Providedassayconcentrationsaresuggestionsonly,14-3-3sigmaantibodytitrationmayberequiredforoptimalresults. |
| USERNOTE: | Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher |
| IMMUNOGEN: | Arecombinantproteinfragmentfromtheinternalregionof14-3-3sigmawasusedastheimmunogenforthisantibody.Theaminoacidsequenceiscommontothe~30kDaand~20kDaisoforms. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | ProteinAaffinitychromatography |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | PBSwith0.1mg/mlBSAand0.05%sodiumazide |
| CONCENTRATION: | 0.5mg/mL |
| STORAGECONDITIONS: | AliquotandStoreat-20C.Avoidfreez-thawcycles. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | 14-3-3proteinsigma,EpithelialcellMarkerprotein1,Stratifin,SFN,HME1 |
|---|---|
| OFFICIALSYMBOL: | SFN |
| GENEID: | 2810 |
Background
| BACKGROUND: | 14-3-3proteinsareregulatorsofadiversegroupofsignalingproteins,includingkinases,phosphatases,andtransmembranereceptors,andhaverolesinawiderangeofphysiologicalprocessesincludingtranscription,intracellularsignaling,cellcyclecontrolandapoptosis.Thereareseven14-3-3proteinsinmostmammals:beta,gammaepsilon,zeta,eta,sigmaandtau.14-3-3sigma,alsocalledStratifin,isaproductoftheSFNgene.ItisatumorsuppressorgeneinactivatedviaDNAmethylation.Reducedornoexpressionof14-3-3sigmaisseeninvariouscarcinomaincludingskin,breastandprostate,suggestingthat14-3-3genesilencingmaybeinvolvedintumorprogression. |
|---|
