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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIESREACTIVITY: | Human,Mouse,Rat |
|---|---|
| TESTEDAPPLICATIONS: | WB |
| APPLICATIONS: | WesternBlot:1:500~1:1000 |
| PREDICTEDMOLECULARWEIGHT: | 18kDa |
| SPECIFICITY: | ThisantibodydetectsendogenousleveloftotalSynucleinprotein. |
| IMMUNOGEN: | a-Synuclein(Ab-129)antibodywasraisedagainstapeptidesequencearoundaa.127~131(M-P-S-E-E)derivedfromHumanα-Synuclein. |
| HOSTSPECIES: | Rabbit |
Properties
| PURIFICATION: | Antibodieswerepurifiedbyaffinity-chromatographyusingepitope-specificpeptide. |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | Antibodysuppliedinphosphatebufferedsaline(withoutMg2+andCa2+),pH7.4,150mMNaCl,0.02%sodiumazideand50%glycerol. |
| CONCENTRATION: | 1mg/mL |
| STORAGECONDITIONS: | Storeantibodyat-20˚Cforuptooneyear. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
AdditionalInfo
| ALTERNATENAMES: | PD1,NACP,PARK1,PARK4,SYN,SYUA,alpha-synuclein |
|---|---|
| ACCESSIONNO.: | NP_000336.1 |
| PROTEINGINO.: | 4507109 |
| OFFICIALSYMBOL: | SNCA |
| GENEID: | 6622 |
Background
| BACKGROUND: | SncAisamemberofthesynucleinfamilyofstructurallyrelatedproteinsthatareprominentlyexpressedinthecentralnervoussystem,whichalsoincludesbeta-andgamma-synuclein.SynucleinsareabundantlyexpressedinthebrainandSncAandSnc-BetainhibitphospholipaseD2selectively.SncAmayservetointegratepresynapticsignalingandmembranetrafficking.AggregatedSncAproteinsformbrainlesionsthatarehallmarksofneurodegenerativesynucleinopathies.DefectsinSncAplayaroleinthepathogenesisofParkinsondisease.SncApeptidesareamajorcomponentofamyloidplaquesinthebrainsofpatientswithAlzheimerdisease.SncAshares95%sequencehomologywithratSncA.RatSncAisspecificallyexpressedinbrainandisassociatedwithsynaptosomalmembranesinneurons |
|---|---|
| REFERENCES: | 1)TakahashiT,etal.JBiolChem2003Oct24;278(43):42225-33AhnBH,etal.JBiolChem2002Apr05;277(14):12334-42NegroA,etal.FASEBJ2002Feb;16(2):210-2Goldberg,etal.Nat.CellBiol.2000;2,115-119. |
