Details:
Tested Applications	WB, ELISA
Target Information	Sigma S is a 38kDa transcription factor of E. coli RNA Polymerase
Product Format	Ascites
Alternate Names	Sigma 38, rpoS, appR, katF, nur, otsX, sigS
Clone	1RS1
Host	Mouse
Isotype	IgG1
Immunogen	Recombinant Protein
Epitope	a.a. 33 - 256
Relevance	Sigma transcription factor controlling a regulation of genes required for protection against external stresses. Possibly, it affects the expression of katE (catalase HPII), xthA (endonuclease III), the appABC operon and other genes by modifying the affinity of RNA polymerase for the promoters.
Specificity	E. coli Sigma S (Strain MG1655)
Reported Reactivity	E. coli, Klebsiella, Salmonella, Serratia, Bordetella and an unidentified protein at 60 kDA
Reported Applications	Transcription inhibition

What's Happening at NeoClone Biotechnology You're probably wondering, "Now that BioLegend owns all your former catalog products, what the heck are you doing up there in Madison?" I'm glad you asked. We're still making great monoclonal antibodies, of course! NeoClone has been making custom murine antibodies via hybridoma technology for years. In fact, that's where our catalog came from in the first place! We decided that we needed to return our focus to custom projects, especially the really difficult targets that researchers had been bringing us all along. You know, the targets that other companies couldn't make due to problems with tolerance or toxicity or bizarre secondary structures. Then we decided to branch out into other methods of generating antibodies. We brought on new staff with years of experience in Antibody Phage Display and Camelid VHH antibodies. We've been upping our game in the Bioinformatics arena as well, giving us an edge in determining the best way to make YOUR antibody. Unlike other antibody development companies, we're not tied to one particular method. In the world of antibody development, one size does NOT fit all. So, you tell us what you want. We'll make sure we get it for you.