Details:
Tested Applications	WB, ELISA
Target Information	Sigma 70 is a 70kDa transcription factor of E. coli RNA polymerase
Product Format	Ascites
Alternate Names	RNA pol sigma 70, rpoD, sigma D
Clone	2G10
Host	Mouse
Isotype	IgG2b
Immunogen	Recombinant Protein
Epitope	a.a. 470 - 486
Relevance	RNA polymerase transcribes DNA to synthesize RNA. Prokaryotes contain a single RNA polymerase- core RNA polymerase. RNA polymerase sigma 70 (also known as RNA pol sigma 70 and rpoD) is one of a family of sigma factor subunits required for specific promoter recognition and initiation. RNA pol sigma 70 is the major ?housekeeping? sigma factor responsible for RNA polymerase recognition of the majority of promoters necessary to transcribe bacterial genes expressed in expansion.
Specificity	E. coli Sigma 70 (strain MG1655)
Reported Reactivity	Chlamydia trachomatis, Mycobacterium smegmatis, Staphylococcus aureus, Bordetella pertussis, Rhodobacter sphaeroides, Vibrio parahaemolyticus, Pseudamonas aeruginosa, Agrobacterium tumefaciens, Streptocoddus faecalis, Arthrobacter globiformis.Reported not to react with Borellia burgdorferi.
Reported Applications	Transcription inhibition, IP

What's Happening at NeoClone Biotechnology You're probably wondering, "Now that BioLegend owns all your former catalog products, what the heck are you doing up there in Madison?" I'm glad you asked. We're still making great monoclonal antibodies, of course! NeoClone has been making custom murine antibodies via hybridoma technology for years. In fact, that's where our catalog came from in the first place! We decided that we needed to return our focus to custom projects, especially the really difficult targets that researchers had been bringing us all along. You know, the targets that other companies couldn't make due to problems with tolerance or toxicity or bizarre secondary structures. Then we decided to branch out into other methods of generating antibodies. We brought on new staff with years of experience in Antibody Phage Display and Camelid VHH antibodies. We've been upping our game in the Bioinformatics arena as well, giving us an edge in determining the best way to make YOUR antibody. Unlike other antibody development companies, we're not tied to one particular method. In the world of antibody development, one size does NOT fit all. So, you tell us what you want. We'll make sure we get it for you.