快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / MedKoo / MedKoo Biosciences/LGK974 (WNT974)/205851/5g

MedKoo Biosciences/LGK974 (WNT974)/205851/5g

价格
面议
货号：205851-5g
浏览量：59
品牌：MedKoo
服务
全国联保
正品保证
正规发票
签订合同
商品描述
LGK974,asloknownasisaselectiveandorallybioavailablePorcupine(PORCN)inhibitorunderdevelopmentforthetreatmentofcancersthataredrivenbytheWntpathwayinaWntligand-dependentmanner.WNT974bindstoandinhibitsPORCNintheendoplasmicreticulum(ER),whichblockspost-translationalacylationofWntligandsandinhibitstheirsecretion.ThispreventstheactivationofWntligands,interfereswithWnt-mediatedsignaling,andinhibitscellgrowthinWnt-driventumors.Porcupine,amembrane-boundO-acyltransferase(MBOAT),isrequiredforthepalmitoylationofWntligands,andplaysakeyroleinWntligandsecretionandactivity.Wntsignalingisdysregulatedinavarietyofcancers.

MedKooCat#:205851
Name:LGK974(WNT974)
CAS#:1243244-14-5
ChemicalFormula:C23H20N6O
ExactMass:396.16986
MolecularWeight:396.44
ElementalAnalysis:C,69.68;H,5.08;N,21.20;O,4.04


Synonym:LGK974;LGK-974;LGK974;WNT974;WNT974;WNT-974.

IUPAC/ChemicalName:2-(2",3-dimethyl-[2,4"-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

InChiKey:XXYGTCZJJLTAGH-UHFFFAOYSA-N

InChiCode:InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h4-10,12-14H,11H2,1-2H3,(H,27,29,30)

SMILESCode:O=C(NC1=NC=C(C2=NC=CN=C2)C=C1)CC3=CN=C(C4=CC(C)=NC=C4)C(C)=C3


TechnicalData

Appearance:
whitesolidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:
ViewCoA:previousbatch,Lot#BBC41229
ViewCoA:currentbatch,Lot#BBC50728

QCData:
ViewQCdata:previousbatch,Lot#BBC41229
ViewQCdata:currentbatch,Lot#BBC50728

SafetyDataSheet(MSDS):
ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>5yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

  
 
 
 


References

1:LiuJ,PanS,HsiehMH,NgN,SunF,WangT,KasibhatlaS,SchullerAG,LiAG,ChengD,LiJ,TompkinsC,PferdekamperA,SteffyA,ChengJ,KowalC,PhungV,GuoG,WangY,GrahamMP,FlynnS,BrennerJC,LiC,VillarroelMC,SchultzPG,WuX,McNamaraP,SellersWR,PetruzzelliL,BoralAL,SeidelHM,McLaughlinME,CheJ,CareyTE,VanasseG,HarrisJL.TargetingWnt-drivencancerthroughtheinhibitionofPorcupinebyLGK974.ProcNatlAcadSciUSA.2013Dec10;110(50):20224-9.doi:10.1073/pnas.1314239110.Epub2013Nov25.PubMedPMID:24277854;PubMedCentralPMCID:PMC3864356.

2:JiangX,HaoHX,GrowneyJD,WoolfendenS,BottiglioC,NgN,LuB,HsiehMH,BagdasarianL,MeyerR,SmithTR,AvelloM,CharlatO,XieY,PorterJA,PanS,LiuJ,McLaughlinME,CongF.InactivatingmutationsofRNF43conferWntdependencyinpancreaticductaladenocarcinoma.ProcNatlAcadSciUSA.2013Jul30;110(31):12649-54.doi:10.1073/pnas.1307218110.Epub2013Jul11.PubMedPMID:23847203;PubMedCentralPMCID:PMC3732970.

苏州蚂蚁淘代理MedKoo在中国的业务。 MedKoo北京代理，MedKoo华东代理，MedKoo华北代理，MedKoo华中代理，MedKoo华南代理,MedKoo全国代理。 MedKoo公司是2009年由Qingqi Chen博士创立。在美国北卡罗来纳州的三角研究园区有运营办公室，其研发和生产车间位于中国。陈博士在加入MedKoo之前，是中山大学药学院（中山大学，中国广州）和中国科学院（北京）“100人计划”的杰出教授。对小分子抗癌药物有浓厚兴趣，发表了100多篇论文，获得20多项。Medkoo是处于先进地位的小分子抗癌试剂，激酶抑制剂和其他相关化学品的优秀供应商。 MedKoo部分产品列表：MedKoo全国代理 406757 10058-F4 530576 10074-G5 600110 10-Deacetylbaccatin III 530429 10-Gingerol 406281 10-Hydroxycamptothecin 341231 10-Hydroxyyohimbine 571387 [11C]-ABP688 526406 11-deoxy-PGF2a 525629 123C4   561223 12-Crown-4 featured 525697 1,3,5,6-Tetrahydroxyxanthone 526087 1,3,5-Trihydroxyxanthone 584120 1,3,7-Trimethyluric acid 527871 1,3-Dicaffeoylquinic acid 530605 1400W HCl