快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / MedKoo / MedKoo Biosciences/TAK-659 HCl/206169/5mg

MedKoo Biosciences/TAK-659 HCl/206169/5mg

价格
￥2400.00
货号：206169-5mg
浏览量：127
品牌：MedKoo
服务
全国联保
正品保证
正规发票
签订合同
商品描述
TAK-659isaninhibitorofspleentyrosinekinase(syk),withpotentialanti-inflammatory,immunomodulating,andantineoplasticactivities.SpleentyrosinekinaseinhibitorTAK-659mayinhibittheactivityofsyk,whichabrogatesdownstreamB-cellreceptor(BCR)signalingandleadstoaninhibitionofB-cellactivation,chemotaxis,adhesionandproliferation.Note:TAK-659freebaseislessstable.Thisproductissuppliedasdihydrochlorideform.

MedKooCat#:206169
Name:TAK-659HCl
CAS#:1312691-41-0
ChemicalFormula:C17H23Cl2FN6O
ExactMass:
MolecularWeight:417.3104
ElementalAnalysis:C,48.93;H,5.56;Cl,16.99;F,4.55;N,20.14;O,3.83


RelatedCAS#:1312691-41-0(2HCl) 1952251-28-3(HCl) 1312691-33-0(free) 

Synonym:TAK659,TAK-659,TAK659,TAK-659HCl,TAK659dihydrochloride

IUPAC/ChemicalName:6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-onedihydrochloride

InChiKey:BZSLKYUVNSVQRA-UVDYRLMLSA-N

InChiCode:InChI=1S/C17H21FN6O.2ClH/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19;;/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23);2*1H/t11-,12+;;/m0../s1

SMILESCode:O=C1NCC2=C1C(C3=CN(C)N=C3)=NC(N[C@H]4[C@@H](N)CCCC4)=C2F.[H]Cl.[H]Cl


TechnicalData

Appearance:
Whitetooff-whitesolidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:
ViewCoA:currentbatch,Lot#YXM61212

QCData:
ViewQCdata:currentbatch,Lot#YXM61212

SafetyDataSheet(MSDS):
ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


References

1:PurroyN,CarABIaJ,AbrisquetaP,EgiaL,AguilóM,CarpioC,PalacioC,CrespoM,BoschF.InhibitionofBCRsignalingusingtheSykinhibitorTAK-659preventsstroma-mediatedsignalinginchroniclymphocyticleukemiacells.Oncotarget.2016Nov24.doi:10.18632/oncotarget.13557.[Epubaheadofprint]PubMedPMID:27888629.

2:LamB,ArikawaY,CramlettJ,DongQ,deJongR,FeherV,GrimshawCE,FarrellPJ,HoffmanID,JenningsA,JonesB,MatuszkiewiczJ,MiuraJ,MiyakeH,NatalaSR,ShiL,TakahashiM,TaylorE,WyrickC,YanoJ,ZalevskyJ,NieZ.DiscoveryofTAK-659anorallyavailableinvestigationalinhibitorofSpleenTyrosineKinase(SYK).BioorgMedChemLett.2016Dec15;26(24):5947-5950.doi:10.1016/j.bmcl.2016.10.087.PubMedPMID:27839918.

3.PreparationoffusedheteroaromaticpyrrolidinonesasSYKinhibitorsfortreatingimmuneandinflammatorydisorders.ByArikawa,Yasuyoshi;Dong,Qing;Feher,Victoria;Jones,Benjamin;Lam,Betty;Nie,Zhe;Smith,Christopher;Takahashi,Masashi.FromU.S.Pat.Appl.Publ.(2011),US20110152273A120110623.

苏州蚂蚁淘代理MedKoo在中国的业务。 MedKoo北京代理，MedKoo华东代理，MedKoo华北代理，MedKoo华中代理，MedKoo华南代理,MedKoo全国代理。 MedKoo公司是2009年由Qingqi Chen博士创立。在美国北卡罗来纳州的三角研究园区有运营办公室，其研发和生产车间位于中国。陈博士在加入MedKoo之前，是中山大学药学院（中山大学，中国广州）和中国科学院（北京）“100人计划”的杰出教授。对小分子抗癌药物有浓厚兴趣，发表了100多篇论文，获得20多项。Medkoo是处于先进地位的小分子抗癌试剂，激酶抑制剂和其他相关化学品的优秀供应商。 MedKoo部分产品列表：MedKoo全国代理 406757 10058-F4 530576 10074-G5 600110 10-Deacetylbaccatin III 530429 10-Gingerol 406281 10-Hydroxycamptothecin 341231 10-Hydroxyyohimbine 571387 [11C]-ABP688 526406 11-deoxy-PGF2a 525629 123C4   561223 12-Crown-4 featured 525697 1,3,5,6-Tetrahydroxyxanthone 526087 1,3,5-Trihydroxyxanthone 584120 1,3,7-Trimethyluric acid 527871 1,3-Dicaffeoylquinic acid 530605 1400W HCl