AphidicolinisaditerpeneantibioticinitiallyproducedbyCephalosporumthatexhibitsantiviralactivities.AphidicolininhibitseukaryoticDNAreplicationbyinhibitingDNApolymeraseandinducingSphasecellcyclearrest.Inresearchmodels,aphidicolinisusedtostudycellcyclephases.ThiscompoundalsoinhibitsthegrowthofvacciniavirusinvivobyinhibitingviralDNApolymerase.
| CasNo. | 38966-21-1 |
|---|---|
| Purity | ≥98% |
| Formula | C20H34O4 |
| FormulaWt. | 338.48 |
| ChemicalName | (3α,4α,5α,17α)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol |
| Synonym | ICI-69653;NSC-234714 |
| MeltingPoint | 227-232°C |
| Solubility | SolubleinDMSO,ethanol. |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A6229MSDSPDF |
|---|---|
| InfoSheet | A6229InfoSheetPDF |
WillisJ,DeStephanisD,PatelY,etal.StudyoftheDNAdamagecheckpointusingXenopuseggextracts.JVisExp.2012Nov5;(69):e4449.PMID:23149695.
ZhaoYM,LiJY,LanJP,etal.Cellcycledependenttelomereregulationbytelomeraseinhumanbonemarrowmesenchymalstemcells.BiochemBiophysResCommun.2008May16;369(4):1114-9.PMID:8339310.
DeFilippesFM.Effectofaphidicolinonvacciniavirus:isolationofanaphidicolin-resistantmutant.JVirol.1984Nov;52(2):474-82.PMID:6436508.
