Description
Tropisetron is an antagonist at 5-HT3 receptors and partial agonist at α7 nicotinic acetylcholine receptors (nAChRs) that exhibits antiemetic, analgesic, anti-inflammatory, nephroprotective, neuroprotective, and anti-fibrotic activities. In animal models of nephrotoxicity, tropisetron decreases levels of TNF-α, IL-1β, and iNOS and improves renal pathology. Additionally, tropisetron increases survival of glutamatergic neurons by decreasing levels of p38 MAPK and inducing NMDA receptor internalization in vitro. Tropisetron also inhibits collagen synthesis and fibrosis in animal models of scleroderma.
References
Zirak MR, Rahimian R, Ghazi-Khansari M, et al. Tropisetron attenuates cisplatin-induced nephrotoxicity in mice. Eur J Pharmacol. 2014 Jun 4. [Epub ahead of print]. PMID: 24905858.
Swartz MM, Linn DM, Linn CL. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21. PMID: 23727438.
Stegemann A, Sindrilaru A, Eckes B, et al. Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Arthritis Rheum. 2013 Mar;65(3):792-804. PMID: 23440693.
Bandschapp O, Filitz J, Urwyler A, et al. Tropisetron blocks analgesic action of acetaminophen: a human pain model study. Pain. 2011 Jun;152(6):1304-10. PMID: 21420788.
Hsu ES. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther. 2010 Sep-Oct;17(5):476-86. PMID: 20844345.
美国LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。
美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。
官方网站： http://www.lktlabs.com
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