Adapaleneisaderivativeoftretinointhatisclinicallyusedtotreatacneandpityriasisversicolor.Thissyntheticretinoidexhibitsanti-inflammatoryactivity,decreasingexpressionofKi67,α2-integrin,α6-integrin,toll-likereceptor2(TLR2),IL-8,andβ-defensininexvivomodels.Likeotherretinoids,adapalenealsoactivatesretinoicacidreceptorsRARα/β/γacrossseveralmodels.
| CasNo. | 106685-40-9 |
|---|---|
| Purity | ≥98% |
| Formula | C28H28O3 |
| FormulaWt. | 412.52 |
| IUPACName | 6-[3-(1-adamantyl)-4-methoxyphenyl]naphthalene-2-carboxylicacid |
| MeltingPoint | 319-322C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | A1202MSDSPDF |
|---|---|
| InfoSheet | A1202InfoSheetPDF |
Tirado-SánchezA,EspíndolaYS,Ponce-OliveraRM,etal.Efficacyandsafetyofadapalenegel0.1%and0.3%andtretinoingel0.05%foracnevulgaris:resultsofasingle-center,randomized,double-blinded,placebo-controlledclinicaltrialonMexicanpatients(skintypeIII-IV).JCosmetDermatol.2013Jun;12(2):103-7.PMID:23725303.
ShiTW,RenXK,YuHX,etal.Rolesofadapaleneinthetreatmentofpityriasisversicolor.Dermatology.2012;224(2):184-8.PMID:22572567.
ZulianiT,KhammariA,ChaussyH,etal.ExvivodemonstrationofasynergisticeffectofAdapaleneandbenzoylperoxideoninflammatoryacnelesions.ExpDermatol.2011Oct;20(10):850-3.PMID:21793939.
MichelS,JomardA,DémarchezM.Pharmacologyofadapalene.BrJDermatol.1998Oct;139Suppl52:3-7.PMID:9990413.
BernardBA.Adapalene,anewchemicalentitywithretinoidactivity.SkinPharmacol.1993;6Suppl1:61-9.PMID:8142113.
