α-Santonin is a terpene found in Artemisia that exhibits antipyretic, anti-parasitic/anti-helminthic, and antibacterial activities. In animal models, α-santonin decreases body temperature. Derivatives of this compound exhibit other biological activities, including anticancer and anti-inflammatory properties.
| Cas No. | 481-06-1 |
|---|---|
| Purity | ≥98% |
| Formula | C15H18O3 |
| Formula Wt. | 246.30 |
| Chemical Name | [3S-(3α,3aα,5aβ,9bβ)]-3a,5,5a,9b-Tetrahydro-3,5a,9- trimethylnaphthol[1,2-b]furan-2,8(3H,4H)-dione |
| IUPAC Name | (3S,3aS,5aS,9bS)-3,5a,9-trimethyl-3a,4,5,9b-tetrahydro-3H-benzo[g][1]benzofuran-2,8-dione |
| Synonym | (-)-Santonine; Santonin |
| Melting Point | 170-173°C |
| Solubility | Soluble in alcohol, ether and chloroform. |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | S0053 Info Sheet PDF |
|---|
Otoguro K, Iwatsuki M, Ishiyama A, et al. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei. Phytochemistry. 2011 Nov;72(16):2024-30. PMID: 21843897.
Arantes FF, Barbosa LC, Alvarenga ES, et al. Synthesis and cytotoxic activity of alpha-santonin derivatives. Eur J Med Chem. 2009 Sep;44(9):3739-45. PMID: 19406535.
Bharathi A, Polasa H. Elimination of ColE1 group (pBR322 and pBR329) plasmids in Escherichia coli by alpha-santonin. FEMS Microbiol Lett. 1990 Mar 1;56(1-2):213-5. PMID: 2185125.
Martín ML, Morán A, Carrón R, et al. Antipyretic activity of alpha- and beta-santonin. J Ethnopharmacol. 1988 Jul-Aug;23(2-3):285-90. PMID: 3193791.
