Description:

Species	Human
SampleType	Serumorplasma.ForthequantitativedeterminationofhumanHaptoglobinlevelsinserumorotherBIOLOGicalsamples.Blood,PathologicProcesses,HematologicDiseases,BloodCells,Liver.
ProductName	HumanHaptoglobin.
SampleType	Serumorplasma.
#ofSamples	10X96wells.
StorageandStABIlity	-20°C.
RangeofDetection	7.8-500ng/ml.
Shelflife	Oneyearfromdateofreceipt.
AssayCondition	ThekitperformancehasbeenoptimizedfortheprotocolandmaterialslistedbelowusingstandarddilutionsofhumanHaptoglobininthe7.8-500ng/mlrange.Theoperatormustdetermineappropriatedilutionsofreagentsforalternativeassayconditions.ELISAassayreactivityissensitivetovariationsinoperator,pipettingandwashingtechniques,incubationtime,temperature,compositionofreagents,andotherexperimentalvariables.Assayoptimizationmayberequiredtogeneratethestandardcurveandfitthesamplesinthespecifieddetectionrange.
CountryofOrigin	UnitedStatesofAmerica.
AssayUse	ForResearchUseOnly(RUO).Notfordiagnosticortherapeuticuseinhumansoranimals.Notforanimalorhumanconsumption.
Function	Haptoglobincombineswithfreeplasmahemoglobin,preventinglossofironthroughthekidneysandprotectingthekidneysfromdamagebyhemoglobin,whilemakingthehemoglobinaccessIBLetodegradativeenzymes.
Subunit	Tetrameroftwoalphaandtwobetachains.
SubcellularLocation	Secreted.
TissueSpecificity	Expressedbytheliverandsecretedinplasma.
Polymorphism	Inthehumanpopulationstherearetwomajorallelicforms,alpha-1with83residuesandalpha-2with142residues.Theseallelesdeterminethe3majorphenotypesHP*1F/HP*1SandHP*2FS.ThetwomainallelesofHP*1arecalledHP*1F(fast)andHP*1S(slow).
Similarity	BelongstothepeptidaseS1family[viewclassification]. Contains1peptidaseS1domain[viewclassification]. Contains2Sushi(CCP/SCR)domains.

AdditionalInformation:

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Name	HumanHaptoglobinELISAQuantitationKit
RelatedProductNames	HP2-ALPHA,HumanHaptoglobinELISAKit,HumanHaptoglobin,HP
NCBIAccNumber	NP_001119574.1
MolecularWeight	45205
SwissProtNumber	P00738
IntendedUse	ResearchUseOnly