Themammaliancblfamilyofubiquitinligasesconsistsofthreehomologsknownascbl(alsoknownasc-Cbl),Cbl-B,andCbl-3whichsharehighlyconservedatyrosine-kinase-bindingdomain,linkerandRINGfingerdomainintheiramino-terminalhalves.SimilartootherE3ubiquitinligases,CblcatalyzesthetransferofubiquitinfromanE2orUbc(ubiquitin-conjugating)enzymetothee-aminogroupofalysineresidueofthesubstrateprotein.Cblactstonegativelyregulatemanytypesofcell-surfacereceptors,includingtheSykproteintyrosinekinasefamily.CblisthoughttobeinvolvedinT-andB-cellsignaling,inadditiontothymusdevelopment.Ofthethreeknownhomologsinthecblfamily,cblantibodyreactsspecificallywithcbl.Multipleisoformsofcblhavebeenreported. Abbiotec为科学界提供定制抗体生产服务，以加速从生物学到Discovery ™ 的项目  。当尚未获得针对所选抗原的抗体时，就该开发定制项目了。Abbiotec的经验丰富的员工以与开发Abbiotec目录抗体产品相同的思维方式和工具来处理定制项目：我们需要在所选应用中能特异性检测抗原的抗体。