Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import. Abbiotec为科学界提供定制抗体生产服务，以加速从生物学到Discovery ™ 的项目  。当尚未获得针对所选抗原的抗体时，就该开发定制项目了。Abbiotec的经验丰富的员工以与开发Abbiotec目录抗体产品相同的思维方式和工具来处理定制项目：我们需要在所选应用中能特异性检测抗原的抗体。