question 有谁知道:进口试剂Avidity直采 Avidity生物素蛋白连接酶(BirA),是假货吗?

苏州蚂蚁淘生物科技有限公司是一家依托于中科院生命科学领域的高新技术生物公司,致力于生命科学领域产品的研发与销售,蚂蚁淘生物秉承为客户提供高质量产品及优质服务的理念,从事科研机构及生产企业所需的各种品牌生化剂、抗体、血清、ELISA试剂盒、移液枪、中小型仪器设备、耗材等专业进出口公司。主要经营品牌abcam、abnova、peprotech、RD、CST、AbD Serotec、Athens Research Technology、Chemicon 、Evrogen、 Bio-Rad、 Zymed、wako、bachem、Exiqon、Invitrogen、Eppendorf、Bioassay、cayman、TRC、Omega、Promega、Axygen、AssayPro等品牌中国区域.代理商,自成立以来发展迅速,产品服务得到全国广大生产企业、高校、科研院所、医疗系统及相关试剂公司的肯定,我们愿竭尽所能,赛因百奥生物在保证产品质量的基础上将以超低价格为您提供优质服务;同时也为广大经销公司提供充足货源,我们的目标是努力成为国内生物学产品行业专业供应商。


  


Avidity带有AviTag标签的人类全长ORF克隆已经被构建在多种T7和CMV启动子表达系统,可以立即购买使用。AviTag标签蛋白可以被体内或体外的生物素连接酶生物素化,而且抗生物素蛋白或链霉亲和素可以专一地与生物素结合,正基于这两个反应,AviTag?技术可以应用于蛋白的固定,纯化和显影。 虽然Avidity是一个小公司,科学带来的好处及其AviTag已得到认可。目前, AviTag技术已经在22个国家的世界十大制药公司和研究人员中得到认可。 



Avidity Avitag™ Technology

Avidity develops and sells molecular affinity tools for connecting molecules. Our patented AviTag™ technology employs a highly targeted enzymatic conjugation of a single biotin on a unique 15 amino acid peptide tag using the biotin ligase (BirA) from E. coli. AviTag™ sequence is GLNDIFEAQKIEWHE. Oriented on streptavidin-coated surfaces, this creates an ideal presentation for molecular binding interactions.

The scientific benefits of Avidity's AviTag Technology have garnered notice. Currently, AviTag technology is licensed by seven of the world's top ten pharmaceutical companies and is used by researchers in 22 countries.

Company History

Avidity, LLC was founded in 1996 by Millard Cull, Larry Lansing, Dr. Ron Gill, and Dr. Mark Seville to develop peptide tags and molecular biology products based upon the extraordinary affinity of biotin for avidin or streptavidin. While working at Affymax as a researcher, Millard was involved in the discovery of the AviTag technology, saw its commercial potential, and obtained the exclusive rights from Affymax. He started Avidity as a reagent company that sublicenses the right to use the AviTag technology to other companies and sells products for use with the technology.

AviTag History

AviTag is a patented biotin-tagging technology discovered at Affymax by Dr. Peter Schatz from a Directed Evolution approach called "Peptides-on-Plasmids." The Directed Evolution approach identified a number of peptide sequences that can be biotinylated by the BirA enzyme of E. coli, and the best of these sequences was called the AviTag. E. coli enzyme BirA biotinylates the 15 amino acid AviTag twice as fast as its natural substrate, the Biotin Carboxyl Carrier Protein (BCCP).

The enzymatic biotinylation of proteins using AviTag technology is preferred over chemical biotinylation of proteins because BirA enzyme gently, and highly specifically, labels the lysine residue of the AviTag. Prior to the AviTag, the smallest biotin-accepting domain was comprised of 75 amino acids.

蚂蚁淘 2018-07-17