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The protein encoded by this gene is an isozyme of thelong-chain fatty-acid-coenzyme A ligase family. Although differingin substrate specificity, subcellular localization, and tissuedistribution, all isozymes of this family convert free long-chainfatty acids into fatty acyl-CoA esters, and thereby play a key rolein lipid biosynthesis and fatty acid degradation. This isozymepreferentially utilizes arachidonate as substrate. The absence ofthis enzyme may contribute to the mental retardation or Alportsyndrome. Alternative splicing of this gene generates 2 transcriptvariants.
Titration of the FACL4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 28-56 from the human protein was used as the immunogen for this FACL4 antibody.
Aliquot the FACL4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
