Epstein-Barr virus (EBV), also designated human herpesvirus 4 (HHV-4), is a member of the herpesvirus family and is one of the most common human viruses. EBV infects B cells and, though often asymptomatic, it can cause infectious mononucleosis, a disease characterized by fatigue, fever, sore throat and muscle soreness. The EBV-induced early antigens (Ea) are among several antigen complexes that have been identified in EBV-infected cells. The Ea complex is composed of diffuse (EaD) and restricted (EaR) components. The activity of EaD is suppressed during latent infection. BMRF1, the gene that encodes for EaD, is closely associated with the gene encoding for EBV DNA polymerase, and EaD is essential for the activity of this polymerase. EaD forms a complex with EBV DNase and, together, they may play a role in viral replication.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the Early Antigens antibody to be titered up or down for optimal performance.

Affinity purified early antigen polypeptides from induced Raji cells precipitated with African Burkitt"s lymphoma sera were used as the immunogen for this Early Antigens antibody.

Store the EBV Early Antigens antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Human Herpesvirus 4 (HHV4), Early Antigens Antibody