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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The MBD3 gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. [RefSeq]
Optimal dilution of the MBD3 antibody should be determined by the researcher.
A synthetic peptide specific to human MBD3 was used as the immunogen for the MBD3 antibody.
Store the MBD3 antibody at -20oC.
