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This protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency.
The stated application concentrations are suggested starting points. Titration of the AADCantibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 32-61 from the human protein was used as the immunogen for the AADC antibody.
Aliquot the AADC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
